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Eric Dane was expected to make a big return to the spotlight at the 2025 Emmys, joining his Grey’s Anatomy castmates for a 20th-anniversary reunion. However, “McSteamy” was suddenly absent from the stage. The reason was the same serious illness he has been openly discussing since spring: ALS. A fall at his home just days before the ceremony led to hospital treatment for stitches and prevented him from attending the event he had been “really looking forward to.”

For years, Dane charmed audiences as Dr. Mark Sloan on Grey’s Anatomy and later received critical praise for his role in Euphoria. In April 2025, the 52-year-old revealed that he had been diagnosed with amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease. He told People magazine about his diagnosis, expressing gratitude for the support of his wife Rebecca Gayheart and their daughters, Billie and Georgia. He also asked for privacy during this difficult time.

ALS is a progressive neurological disease that gradually weakens muscles, affecting walking, speaking, and breathing. There is currently no cure. Survival times vary, and the disease has affected well-known individuals such as Lou Gehrig, Stephen Hillenburg, and Bryan Randall. Stephen Hawking, a famous patient, lived with ALS for many decades before his death in 2018.

Just one month after his diagnosis, Dane spoke to Diane Sawyer about the rapid changes in his mobility. He explained that initially he thought his hand fatigue was from texting too much, but it soon became clear his dominant right hand was losing function. He said he expected to lose use of his left hand in a few months. Despite the challenges, Dane remained hopeful, stating that he did not see this as the end of his story or himself.

In June, Dane expressed his determination to continue working. He told E! News that staying active in his career helped him stay sharp and positive. He acknowledged setbacks but emphasized that his spirit remained strong. In September, as Grey’s Anatomy prepared a tribute for the Emmys, Dane was set to present alongside former co-star Jesse Williams. However, days before the show, he lost his balance at home and fell, an effect of ALS, resulting in a head injury that required hospital stitches.

This caused him to miss the event, which was disappointing for him. Despite the difficulties, Dane is focusing on advocacy and supporting others affected by neurodegenerative diseases. He said sharing his story is a way to help and serve others. He expressed a determination to face his illness with purpose, saying, “If I’m going out, I’m gonna go out helping somebody.”

For fans who remember him as the confident “McSteamy,” this new chapter reveals a quieter strength. Dane’s journey shows courage in the face of fear and uncertainty. His story is a powerful reminder of life’s fragility and the resilience of the human spirit.